Chitosan-pectin-alginate as a novel scaffold for tissue engineering applications

نویسندگان

  • D Archana
  • Laxmi Upadhyay
  • Joydeep Dutta
چکیده

Chitosan-pectin, chitosan-alginate and chitosan-pectin-alginate scaffolds were prepared by freeze-drying technique. The physicochemical characteristics of the scaffolds were characterized by FTIR and SEM. The biological activities like antibacterial assessment, swelling behavior, biodegradation and cytotoxicity study of the prepared scaffolds were evaluated. The results show high swelling property, good mechanical strength, moderate biodegradable properties, excellent antibacterial activity and cell-viability for chitosan-pectin-alginate ternary scaffold. Hence, it can be served as a potential material for tissue engineering applications.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A novel fabrication of PVA/Alginate-Bioglass electrospun for biomedical engineering application

Objecttive (s): Polyvinylalcohol (PVA) is among the most natural polymers which have interesting properties such as nontoxic nature, biodegradability and high resistance to bacterial attacks making it applicable for tissue scaffolds, protective clothing, and wound healing.Materials and Methods: In the current work, PVA and Na-Alginate nanocomposite scaffolds were prepared using the electrospinn...

متن کامل

An introduction to biodegradable materials for tissue engineering applications.

Tissue generation by autogenous cell transplantation is one of the most promising treatment concepts being developed as it eliminates problems of donor site scarcity, immune rejection and pathogen transfer. Cultured cells are seeded onto a three-dimensional biocompatible scaffold that will slowly degrade and resorb as the soft and hard structures grow and assimilate in vitro and/or in vivo. The...

متن کامل

Novel synthesis strategies for natural polymer and composite biomaterials as potential scaffolds for tissue engineering.

Recent developments in tissue engineering approaches frequently revolve around the use of three-dimensional scaffolds to function as the template for cellular activities to repair, rebuild and regenerate damaged or lost tissues. While there are several biomaterials to select as three-dimensional scaffolds, it is generally agreed that a biomaterial to be used in tissue engineering needs to posse...

متن کامل

PEG-penetrated chitosan–alginate co-polysaccharide-based partially and fully cross-linked hydrogels as ECM mimic for tissue engineering applications

The emerging strategy of tissue engineering for the management of end-stage organ failure and associated complications mainly relies on ECM mimicking scaffolds for neo-tissue genesis. In the current study, novel polyethylene glycol interpenetrated cross-linked hydrogel scaffold based on a co-polysaccharide (PIAC) synthesized from two marine heteropolysaccharides, alginate and chitosan, was desi...

متن کامل

Chitosan-Alginate Biocomposite Containing Fucoidan for Bone Tissue Engineering

Over the last few years, significant research has been conducted in the construction of artificial bone scaffolds. In the present study, different types of polymer scaffolds, such as chitosan-alginate (Chi-Alg) and chitosan-alginate with fucoidan (Chi-Alg-fucoidan), were developed by a freeze-drying method, and each was characterized as a bone graft substitute. The porosity, water uptake and re...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2014